Pathological Anatomy

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The Structural and Molecular Pathology Group, integrated into the Germans Trias i Pujol Research Institute (IGTP), on the Can Ruti Campus, is recognized as a consolidated group by the AGAUR, and carries out translational research in the areas of cancer and other pathologies.

The group, made up of pathologists, biologists, clinicians and biochemists, works on human tissue samples and has as a common strategy the approach, from a morphological perspective rooted in pathological anatomy, to the molecular mechanisms of cancer (cutaneous, lymphoid, gastrointestinal, cerebral, gynecological, etc.) and non-neoplastic pathologies.

It also collaborates with various groups from the same institutions and other national and international.

Below you can find recent publications of the Pathological Anatomy service:

  • Pons L, Hernández L, Urbizu A, Osorio P, Rodríguez-Martínez P, Castella E, Muñoz A, Sanz C, Arnaldo L, Felip E, Quiroga V, Tapia G, Margelí M, Fernandez PL. Pre- and Post-Neoadjuvant Clinicopathological Parameters Can Help in the Prognosis and the Prediction of Response in HER2+ and Triple Negative Breast Cancer. Cancers (Basel). 2023;15:3068. doi: 10.3390/cancers15123068. PMID: 37370679; PMCID: PMC10296027
  • Humaran D, Pérez-Anker J, Fernández PL, Blay L, Pascual I, Castellà E, Pérez L, Puig S, Malvehy J, Julián JF. Unveiling a Surgical Revolution: The Use of Conventional Histology versus Ex Vivo Fusion Confocal Microscopy in Breast Cancer Surgery. Cells. 2024 Oct 12;13(20):1692. doi: 10.3390/cells13201692. PMID: 39451210; PMCID: PMC11506682.
  • Pons L, Hernández-León L, Altaleb A,, Ussene E, Iglesias R, Castillo A, Rodriguez P, Castella E, Quiroga V, Felip E, Cirauqui B, Margelí M, Fernández PL. Conventional and digital Ki67 evaluation and their correlation with molecular prognosis and morphological parameters in luminal breast cancer. Scientific Reports  2022 ;12:8176. doi: 10.1038/s41598-022-11411-5.
  • Cuadras M, Semidey ME, Planas J, de Torres IM, Regis L, Celma A, Trilla E, Ramón Y Cajal S, Medina RA, Congregado B, Marcilla D, Japón MA, Ramirez M, Calatrava-Fons A, Leivar A, Alonso MB, García E, González-Peramato P, Vazquez-Martul D, Concha-López Á, Chantada V, Queipo FJ, Gago JL, Carrato C, Luque RJ, Moreno-Jimenez J, Catalina-Fernández I, León C, Morote J. Molecular Detection of Lymph Node Metastases with One-Step Nucleic Acid Amplification (OSNA) Pooling in Prostate Cancer: The POPCORN Study. Int J Mol Sci. 2024 Dec 17;25(24):13489. doi: 10.3390/ijms252413489. PMID: 39769252; PMCID: PMC11679750.
  • Papaleo N, Climent F, Tapia G, Luizaga L, Azcarate J, Bosch-Schips J, Muñoz-Marmol AM, Salido M, Lome-Maldonado C, Vazquez I, Colomo L. Round-robin testing for LMO2 and MYC as immunohistochemical markers to screen MYC rearrangements in aggressive large B-cell lymphoma. Virchows Arch. 2024 Aug;485(2):307-314. doi: 10.1007/s00428-023-03584-9. Epub 2023 Jun 27. PMID: 37368083; PMCID: PMC11329383.
  • Temprana-Salvador J, López-García P, Castellví Vives J, de Haro L, Ballesta E, Rojas Abusleme M, Arrufat M, Marques F, Casas JR, Gallego C, Pons L, Mate JL, Fernández PL, López-Bonet E, Bosch R, Martínez S, Ramón Y Cajal S, Matias-Guiu X. DigiPatICS: Digital Pathology Transformation of the Catalan Health Institute Network of 8 Hospitals-Planification, Implementation, and Preliminary Results. Diagnostics (Basel). 2022 Mar 30;12(4):852. doi: 10.3390/diagnostics12040852. PMID: 35453900; PMCID: PMC9025604
  • Haspel RL, Genzen JR, Wagner J, Lockwood CM, Fong K; Training Residents in Genomics (TRIG) Working Group. Integration of Genomic Medicine in Pathology Resident Training. Am J Clin Pathol. 2020 ;154:784-791. doi: 10.1093/ajcp/aqaa094. PMID: 32696061

Presentation:

The Pathological Anatomy Service makes the diagnosis of neoplasms and contributes very significantly to the diagnosis of many other types of diseases using the molecular morpho study of cytology, biopsies and surgical pieces. To carry out this task, the fundamental tool is the study by mediating optical microscopy of cytological, histological, histochemical and immunohistochemical preparations. Immunofluorescence, electron microscopy and molecular pathology techniques are also often applied.

The Pathological Anatomy Service of the HUGTP receives the anatomopathological samples generated in three hospitals (HUGTP, Badalona Municipal Hospital, Holy Spirit Hospital) and in several centers of the North Metropolitan Health Region (including primary care, specialized care and ASSIR). The Service has been ISO 9001:2008 certified since 2009 and regularly participates in external quality controls of the Spanish Society of Pathological Anatomy (SEAP).

The professionals of the Service teach Pathological Anatomy in the degrees of Medicine and Biomedical Sciences in the HUGTP Teaching Unit of the Faculty of Medicine of the Autonomous University of Barcelona (UAB). Likewise, specialized teaching is given to a total of 8 doctors residing in the MIR specialization program and also practical teaching to senior technicians of Pathological Anatomy from the Pinar, Bonanova and Guineueta IES.

The professionals of te Service participate very actively in research, both in their own projects and in collaborations with other researchers of the Can Ruti Campus (Germans Trias i Pujol Institute, IMPPC, Josep Carreras Institute, IrsiCaixa, etc.) and have received and currently have competitive funding for projects from the Carlos III Institute, Marató TV3 and AGAUR.

You can download the quality policy at this link.
 

Most outstanding news of the service

Tipus Servei: 6

Correu: anapat.germanstrias@gencat.cat

Docència:

Pregraded Teaching

The service teaches the subject of Pathological Anatomy in the degrees of Medicine and Biomedical Sciences of the Faculty of Medicine of the Autonomous University of Barcelona (UAB).

She also participates in several national and international master's degrees (Master's Degree in Breast Pathology at the UB; Master's Degree in Molecular Pathology, European Society of Pathology, University of Nice, among others).

He has also collaborated with Harvard University in the development of tools for training in molecular pathology of residents) (see https://www.pathologylearning.org/training-residents-in-genomics/).

Reference:

  • Haspel RL, Genzen JR, Wagner J, Lockwood CM, Fong K; Training Residents in Genomics (TRIG) Working Group. Retrieved 2009-08-05. . "State of Genomic Medicine in Pathology". Am J Clin Pathol. 2020 ;154:784-791. "Achimota: Achimota: Achimota: Achimota: Achimota: Achimota: Achimota: Achimota: Achimota: Achimota: Achimota: Achimota. PMID 32696061

 

Postgraded teaching

Since 1985, the service has been accredited for the training of resident doctors in the specialty of Pathological Anatomy (two residents per year).

 

Information for residents

Check out the Teaching Guide.

 

Continuous training

The service offers the Pathological Anatomy Update Course and its own thematic annual courses, aimed at pathologists, residents and technicians of Pathological Anatomy.